Glyco-12 cream is a hydrophilic emollient containing contains Glycolic acid 12%. Glycolic acid specific separate effects on different layers of the skin. On the outer layer of the skin, the epidermis, it appears that the glycolic acid will cause an ungluing of the cells which have stuck together in an unhealthy way.On the deeper layer of the skin, the epidermis, there are microscopically demonstrated effects showing an increase in the deposition of collagen and other proteins which lead to better supported and healthier skin.